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Carnegie stages

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In embryology, Carnegie stages are a standardized system of 23 stages used to provide a unified developmental chronology of the vertebrate embryo.

Contents

The stages are delineated through the development of structures, not by size or the number of days of development, and so the chronology can vary between species, and to a certain extent between embryos. In the human being only the first 60 days of development are covered; at that point the term embryo is usually replaced with the term fetus.

It was based on work by Streeter (1942) and O'Rahilly and Müller (1987). The name "Carnegie stages" comes from the Carnegie Institution of Washington.

While the Carnegie stages provide a universal system for staging and comparing the embryonic development of most vertebrates, other systems are occasionally used for the common model organisms in developmental biology, such as the Hamburger–Hamilton stages in the chick.

Stages

Days are approximate, and reflect the days since the last ovulation before pregnancy ("Postovulatory age").

Stage 1: 1 days

  • fertilization
  • polar bodies
  • Stage 2: 2-3 days

  • cleavage
  • morula
  • compaction
  • Stage 3: 4-5 days

  • blastocyst and blastocoele
  • trophoblast and embryoblast
  • Stage 4: 6 days

  • syncytiotrophoblast
  • cytotrophoblast
  • amniotic ectoderm
  • Stage 5 (a-c): 7-12 days

  • implantation
  • embryonic disk
  • bilaminar germ disk
  • primary yolk sac
  • amniotic cavity
  • Stage 6: c. 17 days

  • primitive streak
  • primitive groove
  • chorionic villi
  • secondary yolk sac
  • Stage 7: c. 19 days

  • gastrulation
  • neural plate
  • start of hematopoiesis
  • notochord
  • Stage 8: c. 23 days

  • primitive pit
  • Stage 9: c. 25 days

  • neural groove
  • neural folds
  • septum transversum
  • placode
  • early heart
  • Stage 10: c. 28 days

  • pharyngeal arches #1 and #2
  • cardiac loop
  • intermediate mesoderm
  • Stage 11: c. 29 days

  • sinus venosus
  • mesonephric duct
  • Stage 12: c. 30 days

  • upper limb buds
  • Stage 13: c. 32 days

  • septum primum
  • foramen primum
  • Stage 14: c. 33 days

  • ureteric bud
  • Stage 16: c. 39 days

  • lower limb buds
  • Stage 17: c. 41 days

  • implementation embryo in posterior uterus wall
  • Stage 18: c. 44 days

  • septum secundum
  • References

    Carnegie stages Wikipedia


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