Bleeth was born in New York City, the daughter of Carina, a model, and Philip Bleeth, a business proprietor. Her father Philip is of Russian-Jewish and German-Jewish descent, and her late mother Carina was of Algerian descent. Phil Bleeth was associated with a group of friends that included Arlo Guthrie and Alice Brock (of "Alice's Restaurant" fame) around the time of Yasmine's birth. Yasmine's earliest known acting role was in a Johnson & Johnson's No More Tears baby shampoo television commercial at age 10 months in 1969. At the age of six, she appeared on Candid Camera. Later that year she appeared in a Max Factor cosmetic advertising campaign with model Cristina Ferrare. Her work in this campaign caught the eye of fashion photographer Francesco Scavullo, who subsequently included her and her mother in his book entitled Scavullo Women.
Total Film magazine quoted Bleeth stating: "When I was a girl I used to have to force boys to kiss me. My toughest friend had to hold them down." She has also stated that she was popular with the boys, and that female classmates had beat her up as a result.
Bleeth starred in her first movie in 1980 at the age of 12. She was cast opposite Buddy Hackett in the feature film Hey Babe! By the time she graduated from high school, she had already been working on the soap opera Ryan's Hope since the age of 16. In 1991, she created the role of LeeAnn Demerest on the soap opera One Life to Live.
When Bleeth was 20, her mother, Carina Bleeth, died from inflammatory breast cancer at the age of 47. Bleeth said that she never accepted the fact that her mother was dying until she took her last breath.
Bleeth's role on Baywatch brought her widespread attention. People named her one of magazine's 50 Most Beautiful People in 1995. She was one of FHM's 100 Sexiest Women in the World every year from 1996–2001, and FHM's U.S. 100 Sexiest Women every year from 2000–03. As a result of her role in Baywatch, Bleeth was offered other roles in television and film. She has been a featured actress in five series and has guest-starred in other shows. During her television career, she continued to work as a model, frequently appearing in swimwear or lingerie. She once had her own line of swimwear called Yaz Wear. She has body measurements of 36-24-35 (Breast-Waist-Hip).
Bleeth accepted a starring role in the short-lived series Titans in 2000. Aaron Spelling was so eager to cast Bleeth in the role of a vixen on Titans that his company convinced CBS to grant her an early release from her Nash Bridges contract. In an interview with Dennis Hensley, she said she delighted in her over-the-top depiction of a crazed beauty queen in the 1997 TV movie Crowned and Dangerous. She said, "I keep my crown from that film on my desk in a little Lucite box. My little brother tried it on once, and I screamed at him, 'Take it off! Take it off!' I get a little nasty about my crown."
She met her future husband, strip club owner Paul Cerrito, at the Promises clinic during her first stay there. Bleeth would later comment, "They say you shouldn't get into any relationship in the first year of sobriety — especially with someone in the program, but Paul and I fell in love immediately." They were married in Santa Barbara, California on August 25, 2002, and now live in Los Angeles and Scottsdale, Arizona.
Bleeth was the 1998 spokesperson for the Lee National Denim Day fundraising campaign, which raises millions of dollars for breast cancer research and education. In 1998 it occurred on October 9, and was called the 'Wear Jeans to Work' campaign. Through Bleeth's help, $5 million was raised on that one day to help the Susan G. Komen Breast Cancer Foundation. Her primary message to women was to pay attention to their bodies; her mother was initially misdiagnosed by a doctor who thought that she was going through early menopause.
Bleeth donated the proceeds of her $10,000 win on Celebrity Jeopardy! to breast cancer research. Bleeth has been a spokesperson for the Susan G. Komen Breast Cancer Foundation who, along with corporate sponsor Ford, put together the nationally run Race for the Cure.
In December 2000, Bleeth voluntarily entered the Malibu-based Promises Rehabilitation Clinic to overcome a cocaine dependence. On September 12, 2001, Bleeth was arrested in Romulus, Michigan, after her car pulled off the highway and wound up on a median on Interstate 94 as she and her future husband, Paul Cerrito, were heading to Detroit Metropolitan Airport. No other cars were involved. Police found four syringes with an injectable form of cocaine in them and a small plastic bag with cocaine residue on it. The next day police conducted a search of her hotel room, and they found more cocaine and drug paraphernalia. In November 2001, through a plea bargain, Bleeth pleaded guilty to possessing less than 25 grams of cocaine and to driving while impaired. She was sentenced in January 2002 to two years of probation and 100 hours of community service. Bleeth's lawyer, Jerry Sabbota, stated that the actress was satisfied with the plea bargain, noting that her record will be cleared of any felonies after she fulfills the terms of her probation. "When all is said and done she'll have a traffic ticket on her record. She wasn't treated any better than anyone else, and she wasn't treated any worse," Sabbota said. Her attorney stated that Bleeth was receiving therapy from the founder of the Promises Rehabilitation Clinic. Bleeth completely fulfilled the terms of her probation as of January 2004, and her record was cleared as previously determined by the plea bargain. In an issue of Glamour from April 2003, Bleeth wrote a three-page article entitled "Back From my Drugs Hell" about her rocky path to recovery, her cocaine addiction, and her struggle to remain sober. Bleeth wrote that her cocaine habit was so severe that she collapsed at a photo shoot for Glamour, and she went without sleep for five days at a time. She wrote that "consciously trying to stay off drugs is now part of my life and always will be."Maximum Surge (cancelled) – Jo
Welcome to My Life (October 1991). Starring role; a series of three one-act plays written by Charlie Loventhal (Second Stage Theater, New York, New York, USA)
Bleeth appeared in The Rembrandts' video This House is Not a Home, a follow-up song to their theme song for Friends.
Golden Raspberry Award1999: Nominated, "Worst Actress" – BASEketball
Soap Opera Digest Awards1986: Nominated, "Outstanding Youth Actor/Actress on a Daytime or Prime Time Serial" – Ryan's Hope
1993: Nominated, "Hottest Female Star" – One Life to Live