Meera Jasmine was born on 15 February 1982 in a Syrian Christian family in Kuttapuzha village, Thiruvalla, Kerala to Joseph and Aleyamma. She was the fourth of five children. She has two sisters, Jiby Sara Joseph and Jeny Susan Joseph, who has also acted in films, and two brothers, one of them, George worked as an assistant cinematographer. She completed her schooling in Bala Vihar, Thiruvalla and Marthoma Residential School, Thiruvalla. She appeared for her Higher Secondary Exams in March 2000. She had enrolled for a BSc degree in Zoology at Assumption College, Changanassery and completed nearly three months when she was spotted by director Blessy (who was then an assistant director to director Lohithadas) and offered a role in Soothradharan.
Meera had initially wanted to study and become a doctor and never had dreamed of becoming a film star. She stated, "I was just an ordinary girl. Never in my wildest dreams did I imagine being in films. I had not acted even in school plays. I never was the artistic type, I never thought I could dance, and I had not even thought of myself as being beautiful". She also said that Lohithadas "is like a father figure and my guru. He initiated me into films with Soothradharan and I owe it all to him".
Meera Jasmine made her debut in the Malayalam film Soothradharan. Her second film was Gramaphone, directed by Kamal, in which she appeared alongside Navya Nair and Dileep. Her role as a Jewish girl was appreciated by Malayalam critics. Her third film was Swapnakkoodu, a romantic comedy alongside Prithviraj, Kunchako Boban, Jayasurya, and Bhavana under director Kamal. Her performance was appreciated and the film was a high commercial success. Among the five main characters, the one who scored the most was again Meera. She rose to fame in Malayalam cinema with the film Kasthooriman directed by her mentor Lohithadas, in which she enacted comedy and sentimental scenes. She received her first Filmfare award for her performance in Kasthooriman. The film was also a success at the box office, running for 100 days. The same year, she acted in T. V. Chandran's acclaimed Padam Onnu Oru Vilapam. She played a 15-year-old Muslim girl who was forced to marry an older man, for which she was awarded a State Award and the National Award in addition with several other awards. It was followed by her performance as Raziya in Perumazhakkalam alongside Kavya Madhavan.
In the film Achuvinte Amma (2005), she enacted the young, adorable character Achu. She then paired with Mohanlal in Rasathanthram (2006). She played as a girl pretending to be a boy in the first half of the film. The film went on to become a commercial success. Her next film with Dileep – Vinodayathra, which again was directed by Sathyan Anthikkad. She was next featured opposite Mammootty in the critically acclaimed film Ore Kadal. The film was showcased in film festivals and won awards. Her performance as an innocent middle class woman won praise from audiences. Media quoted her as, "Matching step with the megastar in this histrionic race is Meera Jasmine, who amazes you with a stunning delineation of her difficult role" . Her next film was Calcutta News with Dileep. Blessy, who introduced her to film field, was the director of Calcutta News. In Innathe Chintha Vishayam (2008), she collaborated with Sathyan Anthikkad for his fourth consecutive film, again opposite Mohanlal, but failed to succeed. Her next films Minnaminnikoottam with Kamal and Rathri Mazha with Lenin Rajendran, which released after a long post-production delay, were box office failures.
More than a year later, she played the role of a playback singer in Rajeev Anchal's Paattinte Palazhy. Though the film was commercially not successful, her character was noted and her performance gave her a comeback. Her next film, Four Friends, was a multi-starrer directed by Saji Surendran. She played the role of a cancer patient in this film. In the 2011 film Mohabbat, she played the lead role opposite Anand Michael and Munna. After a brief hiatus, she began committing films by late-2012. She was keen in choosing more women-centric roles and in Babu Janardhanan's Lisammayude Veedu, a sequel to the 2006 film Achanurangatha Veedu, her role was that of a serial rape victim. She acted opposite Mohanlal in Siddique's comedy film Ladies and Gentleman. Her latest project is Shajiyem's Ms. Lekha Tharoor Kanunnathu, a fantasy film in which she plays a dynamic media person, who unexpectedly starts envisaging happenings that cannot be accepted according to the general perception. She has signed up for Ithinumappuram, a period film based in the 70s, in which she plays a highly orthodox and rich Nair woman who falls in love with someone from a lower caste and gets married against her parents' will.
Meera Jasmine's Tamil debut was Run, directed by Lingusamy, which became a high success in Tamil Nadu and made her a sought-after actress. The successes of Run and her next Bala (2002) gave her the chance to work with the established actors of the Tamil film industry. Though her successive film did not fare as well, she was noticed by director Mani Ratnam who gave her a role in Aayutha Ezhuthu. Meera, who did not know Tamil, worked on her diction, and spoke dubbing for her herself in the film. She later appeared in SS Stanley in Mercury Pookkal. Her latest Tamil film, Mambattiyan got released in December 2011. Meera has acted in 15 Tamil films.
Meera Jasmine became noted in the Telugu film industry with Run, the dubbed version of the same-titled Tamil film. She was in the Telugu films in 2004 with Ammayi Bagundi and Gudumba Shankar but also entered Kannada cinema by co-starring with Puneet Rajkumar in Maurya. Her Kannada film Arasu again with Puneet Rajkumar and Ramya is a hit. Her other Kannada films include Devaru Kotta Thangi and Ijjodu. Ijjodu, in which she played Chenni, a Basavi woman, who ends up becoming a sex worker, was screened at four prestigious domestic film festivals and garnered critical acclaim.
Meera Jasmine's biggest commercial success in Telugu remains Bhadra with Ravi Teja in the male lead. Her other Telugu films are Raraju, Maharadhi, Yamagola Malli Modalayindi, Gorintaku and Maa Ayana Chanti Pilladu, in which she is paired for a second time with Sivaji.
In 2008 she said in an interview that she will be marrying Mandolin Rajesh, "but not for the next two or three years". Meera is married to Anil John Titus on 9 February 2014 who works as an engineer in Dubai.
She offered prayers at Raja Rajeshwara temple at Taliparamba in Kerala where the entry of non-Hindus is prohibited. This led to a controversy and sparked off a protest by Hindu devotees. Later, she paid ₹10,000 (US$160) as penalty to the temple authorities to conduct the purification rituals.
In 2008 she faced an unofficial ban in the Malayalam film industry issued by the Association of Malayalam Movie Artistes (AMMA), after she refused to shoot for Twenty:20, a film distributed by actor Dileep for AMMA. Meera however said that she was not aware of a ban and that she was continuing shooting for Malayalam films.National Film Awards2004 – Best Actress, Paadam Onnu: Oru VilapamKerala State Film Awards2003 – Best Actress, Paadam Onnu: Oru Vilapam, Kasthuri Maan2007 – Best Actress, Ore Kadal.Tamil Nadu State Film Awards2005 – Tamil Nadu State Film Award, Kasthuri Maan
Tamil Nadu Government2008 – Kalaimamani AwardFilmfare Awards South2003 – Filmfare Award for Best Actress, Kasthoorimann2006 – Filmfare Award for Best Actress (Malayalam), Achuvinte Amma2007 – Filmfare Award for Best Actress (Malayalam), Ore KadalAsianet Film Awards2003 – Best Actress Award, Paadam Onnu: Oru Vilapam2004 – Best Actress Award, Perumazhakkalam2005 – Best Actress Award, Achuvinte Amma2007 – Best Actress Award, Ore KadalV. Shantaram Awards2003 – V Shantaram Award for Best Actress, Paadam Onnu: Oru Vilapam.2007 – V Shantaram Award for Best Actress, Ore KadalVanitha Film Awards2004 – Vanitha-Chandrika Film Award For Best Actress, Perumazhakkalam2007 – Vanitha-Nipon Paint Film Award for Best Actress, Ore KadalMathrubhumi Film Awards2003 – Mathrubhumi – Medimix Award for Best Actress, Paadam Onnu: Oru Vilapam2004 – Mathrubhumi – Medimix Award for Best Actress, PerumazhakkalamOther Awards2001 – Bharathan Award For Best Female Debut Actress, Soothradharan2002 – Dinakaran Award For Best Female Debut Actress, Run2003 – National Film Academy Award for Best Actress, Paadam Onnu: Oru Vilapam.2003 – Kaveri-Film Critics Award, Paadam Onnu: Oru Vilapam2003 – Kerala Film Audience Council Award, Paadam Onnu: Oru Vilapam2003 – Kerala Film Critics Association Award, Paadam Onnu: Oru Vilapam2004 – Tikkurishi Award for Best Actress, Perumazhakkalam.2005 – Amrita Film Fraternity Award for Best Actress, Achuvinte Amma2006 – Jeevan TV-Mastro Mania award for Best Actress, Rasathanthram2007 – Dubai AMMA award for Best Actress, Ore Kadal2007 – FOKANA Award for Best Actress, Ore Kadal2007 – Amrita Film Award for Best Actress, Ore Kadal2007 – Sreevidya Puraskaaram (Best Actress), Ore Kadal2007 – Tharangini Film Award for Best Actress, Ore Kadal2008 – Best Actress at 8th Annual Imagine Indian Film Festival, Spain, "Ore Kadal"2008 – Dubai AMMA award for Best Actress, Calcutta News2009 – Veera Pazhassi Awards -Swarna Mayoogam