Trisha Shetty (Editor)


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Latin  Trachea
FMA  7394
MeSH  A04.889

Artery  tracheal branches of inferior thyroid artery
Vein  brachiocephalic vein, azygos vein accessory hemiazygos vein

The trachea, colloquially called the windpipe, is a cartilaginous tube that connects the pharynx and larynx to the lungs, allowing the passage of air, and so is present in almost all air-breathing animals with lungs. The trachea extends from the larynx and branches into the two primary bronchi. At the top of the trachea the cricoid cartilage attaches it to the larynx. This is the only complete ring, the others being incomplete rings of reinforcing cartilage. The trachealis muscle joins the ends of the rings and these are joined vertically by bands of fibrous connective tissue – the annular ligaments of trachea. The epiglottis closes the opening to the larynx during swallowing.


The trachea develops in the second month of development. It is lined with an epithelium that has goblet cells which produce protective mucins. An inflammatory condition, also involving the larynx and bronchi, called croup can result in a barking cough. A tracheotomy is often performed for ventilation in surgical operations where needed. Intubation is also carried out for the same reason by the inserting of a tube into the trachea. From 2008, operations have transplanted a windpipe grown by stem cells, and synthetic windpipes; their success is however doubtful.


The trachea of an adult has an inner diameter of about 1.5 to 2 centimetres (0.6 to 0.8 in) and a length of about 10 to 11 centimetres (4 to 4 in). It begin at the bottom of the larynx, and ends at the carina, the point where the trachea branches into left and right main bronchi. The trachea begins level with the sixth cervical vertebra and the carina is found at the level of the fifth thoracic vertebra (T5), opposite the sternal angle and can be positioned up to two vertebrae lower or higher, depending on breathing.

The trachea is surrounded by rings of hyaline cartilage; these rings are incomplete and C-shaped, except for the first ring, called the cricoid cartilage. The cricoid cartilage is attached to the top of the trachea and acts as the bottom of the larynx. There are fifteen to twenty rings in total, separated by narrow intervals. These reinforce the front and sides of the trachea to protect and maintain the airway.

In front of the rings lies connective tissue and skin. Several other structures pass or sit over it; the jugular arch, which joins the two anterior jugular veins, sits in front of the upper part of the trachea. The sternohyoid and sternothyroid muscles stretch along its length, and the thyroid gland sits below this; with the isthmus of the gland overlying the second to fourth rings.

The first tracheal ring is broader than the rest, and often divided at one end; it is connected by the cricotracheal ligament with the lower border of the cricoid cartilage, and is sometimes blended with the next cartilage down. The last cartilage is thick and broad in the middle, due to its lower border being prolonged into a triangular hook-shaped (uncinate) process, which curves downward and backward between the two bronchi. It ends on each side in an imperfect ring, which encloses the commencement of the bronchus. The cartilage above the last is somewhat broader than the others at its center.

Two or more of the cartilages often unite, partially or completely, and they are sometimes bifurcated at their extremities. The rings are generally highly elastic but they may calcify with age.

The trachealis muscle connects the ends of the incomplete rings and contracts during coughing, reducing the size of the lumen of the trachea to increase the rate of air flow. The esophagus lies posteriorly to the trachea, adjoining along the tracheoesophageal stripe. Circular horizontal bands of fibrous tissue called the annular ligaments of trachea join the tracheal rings together. The cartilaginous rings are incomplete to allow the trachea to collapse slightly so that food can pass down the esophagus. A flap-like epiglottis closes the opening to the larynx during swallowing to prevent swallowed matter from entering the trachea.


In the fourth week of development of the human embryo as the respiratory bud grows, the trachea separates from the foregut through the formation of tracheoesophageal ridges which fuse to form the tracheoesophageal septum and this separates the future trachea from the oesophagus and divides the foregut tube into the laryngotracheal tube. Before the end of the fifth week, the trachea begins to develop from the laryngotracheal tube which develops from the laryngotracheal groove. The first part of the cephalic region of the tube forms the larynx, and the next part forms the trachea.

The trachea is no more than 4mm diameter during the first year of life, expanding to its adult diameter by late childhood. The trachea is more mobile and of more variable length, deeper, and smaller in children.


The trachea is lined with a layer of pseudostratified ciliated columnar epithelium. The epithelium contains goblet cells, which are glandular, modified simple columnar epithelial cells that produce mucins, the main component of mucus. Mucus helps to moisten and protect the airways. Mucus lines the ciliated cells of the trachea to trap inhaled foreign particles that the cilia then waft upward toward the larynx and then the pharynx where it can be either swallowed into the stomach or expelled as phlegm. This self-clearing mechanism is termed mucociliary clearance.


Inflammation of the trachea is known as tracheitis. When the trachea is inflamed as well as the larynx and bronchi, this is known as croup, which often causes a distinct, barking cough.


Tracheal intubation refers to the insertion of a catheter down the trachea. This procedure is commonly performed during surgery, in order to ensure a person receives enough oxygen when sedated. The catheter is connected to a machine that monitors the airflow, oxygenation and several other metrics. This is often one of the responsibilities of an anesthetist during surgery. The epiglottic vallecula is an important anatomical landmark for carrying out this procedure. In an emergency, or when tracheal intubation is deemed impossible, a tracheotomy is often performed to insert a tube for ventilation, usually when needed for particular types of surgery to be carried out so that the airway is kept open for sufficient time. Another less invasive method is used when a procedure can be carried out more quickly, or in an emergency situation, and this is a cricothyrotomy.

Congenital disorders

Tracheal agenesis, is a rare birth defect in which the trachea fails to develop. The defect is usually fatal though sometimes surgical intervention has been successful.

A tracheoesophageal fistula is a congenital defect in which the trachea and esophagus are abnormally connected.

Sometimes as an anatomical variation one or more of the tracheal rings are completely formed. These O rings are smaller than the normal C-shaped and can cause narrowing of the trachea resulting in breathing difficulties. An operation called a slide tracheoplasty can be performed which opens up the rings and rejoins them as wider rings shortening the length of the trachea. Slide tracheoplasty is said to be the best option in treating tracheal stenosis.

Mounier-Kuhn syndrome is a very rare congenital disorder of an abnormally enlarged trachea.


  • A tracheo-oesophageal puncture is a surgically created hole between the trachea and the esophagus in a person who has had a total laryngectomy, (removal of larynx). The purpose of the puncture is to restore a person’s ability to speak after the vocal cords have been removed.
  • Tracheomalacia (weakening of the tracheal cartilage)
  • Tracheal collapse (in dogs)
  • Tracheobronchial injury (perforation of the trachea or bronchi)
  • A chondrolaryngoplasty commonly called a tracheal shave is the shaving of the cricoid cartilage in order to reduce it to lessen the prominence of the Adam's apple. It is often carried out in transgender surgery.
  • Other animals

    Allowing for variations in the length of the neck, the trachea in other mammals is, in general, similar to that in humans. Generally, it is also similar to the reptilian trachea.


    In birds, the trachea runs from the pharynx to the syrinx, from which the primary bronchi diverge. Swans have an unusually elongated trachea, part of which is coiled beneath the sternum; this may act as a resonator to amplify sound. In some birds, the tracheal rings are complete, and may even be ossified.

    In amphibians, the trachea is normally extremely short, and leads directly into the lungs, without clear primary bronchi. A longer trachea is, however, found in some long-necked salamanders, and in caecilians. While there are irregular cartilagenous nodules on the amphibian trachea, these do not form the rings found in amniotes.

    The only vertebrate to have lungs, but no trachea, is Polypterus, in which the lungs arise directly from the pharynx.


    The invertebrate trachea refers to the open respiratory system composed of spiracles, tracheae, and tracheoles that terrestrial arthropods have to transport metabolic gases to and from tissues. The distribution of spiracles can vary greatly among the many orders of insects, but in general each segment of the body can have only one pair of spiracles, each of which connects to an atrium and has a relatively large tracheal tube behind it. The tracheae are invaginations of the cuticular exoskeleton that branch (anastomose) throughout the body with diameters from only a few micrometres up to 0.8 mm. The smallest tubes, tracheoles, penetrate cells and serve as sites of diffusion for water, oxygen, and carbon dioxide. Gas may be conducted through the respiratory system by means of active ventilation or passive diffusion. Unlike vertebrates, insects do not generally carry oxygen in their haemolymph. This is one of the factors that may limit their size.

    A tracheal tube may contain ridge-like circumferential rings of taenidia in various geometries such as loops or helices. In the head, thorax, or abdomen, tracheae may also be connected to air sacs. Many insects, such as grasshoppers and bees, which actively pump the air sacs in their abdomen, are able to control the flow of air through their body. In some aquatic insects, the tracheae exchange gas through the body wall directly, in the form of a gill, or function essentially as normal, via a plastron. Note that despite being internal, the tracheae of arthropods are shed during moulting (ecdysis).

    Artificial trachea

    Several bioengineering approaches have been tested to repair and replace the trachea.

    Society and culture

    In 2008, a Colombian woman, Claudia Castillo (30), received a trachea transplant using her own stem cells.

    Between 2011 and 2014 Paolo Macchiarini of the Karolinska University Hospital performed eight operations in which he generated an artificial trachea from a person's stem cells; four of them at Karolinska, three in Russia, and one in Illinois. In January 2016 the Swedish television station Sveriges Television broadcast a three part documentary about Macchiarini that suggested that Macchiarini did not obtain informed consent from these people, six of whom died. Macchiraini had been a "media darling" and had been seen as a pioneer in the field. In February 2016 Karolinska announced it would not renew his contract when it expired in November 2016 and that it would open an investigation of Macchiarini's work and publications.


    Trachea Wikipedia