Drains to liver sinusoid MeSH A07.231.908.670.567 | Latin vena portae hepatis Dorlands
/Elsevier v_05/12851372 | |
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Drains from Gastrointestinal tract, spleen, pancreas Source splenic vein, superior mesenteric vein, inferior mesenteric vein | ||
The portal vein or hepatic portal vein is a blood vessel that carries blood from the gastrointestinal tract, gallbladder, pancreas and spleen to the liver. This blood is rich in nutrients that have been extracted from food, and the liver processes these nutrients; it also filters toxins that may have been ingested with the food. 75% of total liver blood flow is through the portal vein, with the remainder coming from the hepatic artery proper. The blood leaves the liver to the heart in the hepatic veins.
Contents
- Structure
- Portacaval anastomoses
- Accessory hepatic portal veins
- Function
- Portal hypertension
- Pylephlebitis
- References
The portal vein is not a true vein, because it conducts blood to capillary beds in the liver and not directly to the heart. It is a major component of the hepatic portal system, one of only two portal venous systems in the body – with the hypophyseal portal system being the other.
The portal vein is usually formed by the confluence of the superior mesenteric and splenic veins and also receives blood from the inferior mesenteric, gastric, and cystic veins.
Conditions involving the portal vein cause considerable illness and death. An important example of such a condition is elevated blood pressure in the portal vein. This condition, called portal hypertension, is a major complication of cirrhosis.
Structure
Measuring approximately 8 cm (3 inches) in adults, the portal vein is located in the right upper quadrant of the abdomen, originating behind the neck of the pancreas.
In most individuals, the portal vein is formed by the union of the superior mesenteric vein and the splenic vein. For this reason, the portal vein is occasionally called the splenic-mesenteric confluence. Occasionally, the portal vein also directly communicates with the inferior mesenteric vein, although this is highly variable. Other tributaries of the portal vein include the cystic and gastric veins.
Immediately before reaching the liver, the portal vein divides into right and left. It ramifies further, forming smaller venous branches and ultimately portal venules. Each portal venule courses alongside a hepatic arteriole and the two vessels form the vascular components of the portal triad. These vessels ultimately empty into the hepatic sinusoids to supply blood to the liver.
Portacaval anastomoses
The portal venous system has several anastomoses with the systemic venous system. In cases of portal hypertension these anastamoses may become engorged, dilated, or varicosed and subsequently rupture.
Accessory hepatic portal veins
Accessory hepatic portal veins are those veins that drain directly into the liver without joining the hepatic portal vein. These include the paraumbilical veins as well as veins of the lesser omentum, falciform ligament, and those draining the gallbladder wall.
Function
The portal vein and hepatic arteries form the liver's dual blood supply. Approximately 75% of hepatic blood flow is derived from the portal vein, while the remainder is from the hepatic arteries.
Unlike most veins, the portal vein does not drain into the heart. Rather, it is part of a portal venous system that delivers venous blood into another capillary system, the hepatic sinusoids of the liver. In carrying venous blood from the gastrointestinal tract to the liver, the portal vein accomplishes two tasks: it supplies the liver with metabolic substrates and it ensures that substances ingested are first processed by the liver before reaching the systemic circulation. This accomplishes two things. First, possible toxins that may be ingested can be detoxified by the hepatocytes before they are released into the systemic circulation. Second, the liver is the first organ to absorb nutrients just taken in by the intestines. After draining into the liver sinusoids, blood from the liver is drained by the hepatic vein.
Portal hypertension
Increased blood pressure in the portal vein, called portal hypertension, is a major complication of liver disease, most commonly cirrhosis. Signs of portal hypertension include those of chronic liver disease: ascites, esophageal varices, spider nevi, caput medusae, and palmar erythema.
Pylephlebitis
Pylephlebitis is infection of the portal vein, usually arising from an infectious intraabdominal process such as diverticulosis.