Expanding to film and television, Mantegna is best known for his roles in box office hits including Three Amigos (1986), The Godfather Part III (1990), Forget Paris (1995) and Up Close & Personal (1996). As of the 2015–2016 TV season, he stars in the CBS television series Criminal Minds as FBI Supervisory Special Agent David Rossi. Since the 1991 episode "Bart the Murderer", Mantegna has had a recurring role on the animated series The Simpsons as mob boss Fat Tony, reprising the role in The Simpsons Movie (2007).
Additionally, he played Robert B. Parker's fictional detective Spenser in three made-for-TV movies between 1999 and 2001, and has narrated several audiobook readings of the Spenser novels.
An avid firearm enthusiast, he is the host of MidwayUSA's "Gun Stories" on the cable television Outdoor Channel.
Of Italian and Sicilian descent, Mantegna was born in 1947 in Chicago, Illinois, to Mary Ann (Novelli), a shipping clerk from Acquaviva delle Fonti, Italy who died in 2017 at the age of 101, and Joseph Henry Mantegna, an insurance salesman from Calascibetta, Sicily who died in 1971 of tuberculosis.
Mantegna was raised Catholic and attended J. Sterling Morton High School East in Cicero, Illinois. He studied acting at the Goodman School of Drama at DePaul University from 1967-69.
As a young man in Chicago, he played bass in a band called The Apocryphals, which later played with another local group, The Missing Links, who went on to form the band Chicago. Mantegna is still very close to the original members of Chicago and keeps in touch with his old bandmates as well.
Mantegna made his acting debut in the 1969 stage production of Hair and debuted on Broadway in Working (1978). He co-wrote Bleacher Bums, an award-winning play which was first performed at Chicago's Organic Theater Company, and was a member of its original cast. In the movie Xanadu (1980), he had a small role which was cut, although since his name is in the film's credits, Mantegna gets residuals for the film.
Mantegna won a Tony award for his portrayal of Richard Roma in David Mamet's play Glengarry Glen Ross. He has had a long and successful association with Mamet, appearing in a number of his works.
Mantegna made his feature film debut in Medusa Challenger (1977). He played womanizing dentist Bruce Fleckstein in Compromising Positions (1985). He starred in an episode of The Twilight Zone in 1985 called Shelter Skelter. His other early film roles were supporting performances in The Money Pit (1986), Weeds (1987) and Suspect (1987).
He also starred in the critically acclaimed movies House of Games (1987) and Things Change (1988), both written by Mamet. He and Things Change co-star Don Ameche received the Best Actor Award at the Venice Film Festival. In 1991, Mantegna starred in another Mamet story, the highly praised police thriller Homicide.
Mantegna has played a wide range of roles, from the comic—as a fed up shock jock in Airheads and the hilariously inept kidnapper from Baby's Day Out—to the dramatic, in roles such as Joey Zasa, a treacherous mobster in The Godfather Part III (1990) and an Emmy-nominated performance as singer Dean Martin in HBO's film The Rat Pack (1998).
Mantegna has a recurring role in the animated series The Simpsons as the voice of mob boss Anthony "Fat Tony" D'Amico. He insists on voicing the character every time he appears, no matter how little dialogue he has. To quote: "If Fat Tony sneezes, I want to be there." However, in one instance, Phil Hartman voiced Fat Tony in the episode "A Fish Called Selma".
Mantegna spoofed himself when he hosted Saturday Night Live for the 1990–1991 season in which he calmly began his monologue by saying he did not wish to be typecast from his gangster roles. A disappointed little boy and his father leave, as they mistakenly believed the host would be Joe Montana (football player) due to the similar names. Mantegna then began speaking in a low, controlled voice to the little boy, telling him it was best to stay in the audience and respect his performance; he warned the boy that if he (Mantegna) made a call, then Montana would not play in his next game—an implication that Mantegna's true personality equaled his gangster roles.
In 2002, Mantegna starred as Associate Justice of the Supreme Court of the United States, Justice Joseph Novelli, on the CBS midseason replacement drama First Monday.
Mantegna received the Lifetime Achievement Award on April 26, 2004, at the Los Angeles Italian Film Festival. On August 11, 2007, Mantegna signed on to replace departing star Mandy Patinkin on the CBS crime drama Criminal Minds. Since season 9, he has directed several episodes as well.
Since 2006, he has co-narrated the National Memorial Day Concert on the Mall in Washington, D.C. with Gary Sinise.
In 2016 he took part in an event at the Los Angeles County Museum of Art reading some of Gabriele Tinti's poems about Hercules
On April 29, 2011, Mantegna received the 2,438th star on the Hollywood Walk of Fame.
On June 6, 2011, Mantegna's hometown of Cicero celebrated his body of work with an honorary street sign—Joe Mantegna Boulevard—on the northeast corner of Austin Boulevard and 25th Street, the location of his high school.
In 2014, Mantegna was received a star on the Italian Walk of Fame in Toronto, Ontario, Canada.
On April 4, 2015, Mantegna received a Lifetime Achievement Award for Film and Television from The Riverside International Film Festival.
On May 22, 2015, Mantegna received the Saint Pio Award from the Saint Pio Foundation, in recognition of his outstanding contribution in being an extraordinary individual in "providing relief from suffering to those in need."
On May 3, 2017, the city of Chicago dedicated Joe Mantegna Way, a section of Armitage Avenue where Mantegna lived during his early acting days.
Mantegna married Arlene Vrhel on December 3, 1975 and they have two daughters: Mia and Gia. Arlene owns a Chicago-themed restaurant in Burbank, California named Taste Chicago. Mia, born 1987, is autistic and works as a make-up artist. She has also appeared publicly with her father on KCAL-TV in support of Autism Awareness Month (April). Gina was born in 1990 and changed her name to Gia at age eighteen.
Mantegna is a Chicago Cubs fan and has led the singing of "Take Me Out to the Ball Game" during the 7th inning stretch multiple times. This was referenced in the show Criminal Minds where his character David Rossi's office is decked with Cubs gear.
In August 2015, Mantegna conducted an auction of two rifles donated by IWI US (an American subsidiary of Israel Weapon Industries), at an event in Corona, California, in order to raise money for the Friends of the Israel Defense Forces, a group that provides educational and social services for Israeli soldiers.