Harman Patil (Editor)

Hypusine

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Related compounds
  
Palmitoylethanolamide

Molar mass
  
233.308 g/mol

Formula
  
C10H23N3O3

Hypusine httpswwwresearchgatenetprofileMarioPinkpu

Related alkanoic acids
  
4-(γ-Glutamylamino)butanoic acidSaccharopine

How to pronounce hypusine


Hypusine is an unusual amino acid found in all eukaryotes and in some archaea, but not in bacteria. The only known protein containing hypusine is eukaryotic translation initiation factor 5A (eIF5A) and a similar protein found in archaebacteria. In humans, two isoforms of eIF-5A have been described: eIF5A-1 and eIF5A-2. They are encoded by two different genes EIF5A and EIF5A2. The protein is involved in protein biosynthesis and promotes the formation of the first peptide bond. The region surrounding the hypusine residue is highly conserved and is essential to the function of eIF5A. Thus, hypusine and eIF-5A appear to be vital for the viability and proliferation of eukaryotic cells.

Hypusine Scheme of hypusine biosynthesis in eIF5A Figure 1 of 5

Hypusine is formed in eIF-5A by post-translational modification of one of the lysyl residues. There are two reactions and two enzymes involved:

Hypusine A tumour suppressor network relying on the polyaminehypusine axis

  • 1. Deoxyhypusine synthase catalyzes the cleavage of the polyamine spermidine and transfer of its 4-aminobutyl moiety to the ε-amino group of one specific lysine residue of the eIF-5A precursor to form deoxyhypusine and 1,3-diaminopropane.
  • 2. Deoxyhypusine hydroxylase mediates the formation of hypusine by addition of a hydroxyl group to the deoxyhypusine residue.

  • Hypusine Research Klemke Lab

    An excess of hypusine was found in the urine of children and patients with familial hyperlysinemia.

    Hypusine was first isolated from bovine brain by Japanese scientists Shiba et al. in 1971. The name hypusine indicates that the molecule comprises moieties of hydroxyputrescine and lysine.

    Hypusine Is the eIF5A 80S ribosome binding hypusinedependent

    Hypusine JCI Revisiting an old acquaintance role for eIF5A in diabetes

    Hypusine FileHypusinesvg Wikipedia

    References

    Hypusine Wikipedia