Deoxyhypusine monooxygenase

In enzymology, a deoxyhypusine monooxygenase (EC 1.14.99.29) is an enzyme that catalyzes the chemical reaction

protein N₆-(4-aminobutyl)-L-lysine + AH₂ + O₂ ⇌ protein N₆-[(R)-4-amino-2-hydroxybutyl]-L-lysine + A + H₂O

The 3 substrates of this enzyme are a protein-bound N₆-(4-aminobutyl)-L-lysine, an electron acceptor AH₂, and O₂, and its 3 products are protein-bound N₆-[(R)-4-amino-2-hydroxybutyl]-L-lysine, the reduction product A, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O₂ as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating). Other names in common use include deoxyhypusine hydroxylase, and deoxyhypusine dioxygenase.