Samiksha Jaiswal

EIF2S1

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Species  Human
Entrez  1965
Human  Mouse
Ensembl  ENSG00000134001
EIF2S1 AntiEIF2S1 Antibody clone 5A5 for IHC ICC IFImmunofluorescence
Aliases  EIF2S1, EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A, eukaryotic translation initiation factor 2 subunit alpha
External IDs  MGI: 95299 HomoloGene: 3020 GeneCards: EIF2S1

Eukaryotic translation initiation factor 2 subunit 1 (eIF2α) is a protein that in humans is encoded by the EIF2S1 gene.

Contents

EIF2S1 EIF2S1 Gene GeneCards IF2A Protein IF2A Antibody

Function

EIF2S1 antiEIF2S1 antibody AA 1316 Product No ABIN393738

The protein encoded by this gene is the alpha (α) subunit of the translation initiation factor eIF2 complex which catalyzes an early regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA (Met-tRNAiMet) to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, eIF2, and GTP. eIF2 is composed of 3 nonidentical subunits, alpha (α, 36 kD, this article), beta (β, 38 kD), and gamma (γ, 52 kD). The rate of formation of the ternary complex is modulated by the phosphorylation state of eIF2α.

Clinical significance

EIF2S1 Schizophrenia pathways

After reperfusion following brain ischemia, there is inhibition of neuron protein synthesis due to phosphorylation of eIF2α. There is colocalization between phosphorylated eIF2α and cytosolic cytochrome c, which is released from mitochondria in apoptosis. Phosphorylated Eif2-alpha appeared before cytochrome c release, suggesting that phosphorylation of eIF2α triggers cytochrome c release during apoptotic cell death.

EIF2S1 httpsuploadwikimediaorgwikipediacommonsthu

Mice heterozygous for the S51A mutation become obese and diabetic on a high-fat diet. Glucose intolerance resulted from reduced insulin secretion, defective transport of proinsulin, and a reduced number of insulin granules in beta cells. Hence proper functioning of eIF2α appears essential for preventing diet-induced type II diabetes.

Dephosphorylation inhibitors

EIF2S1 EIF2S1 Wikipedia

Salubrinal is a selective inhibitor of enzymes that dephosphorylate eIF2α. Salubrinal also blocks eIF2α dephosphorylation by a herpes simplex virus protein and inhibits viral replication. eIF2α phosphorylation is cytoprotective during endoplasmic reticulum stress.

EIF2S1 AntiEIF2S1 antibody EIF2a ab5369 Abcam

References

EIF2S1 Wikipedia


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