Entrez 933 | Ensembl ENSG00000012124 | |
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Aliases CD22, SIGLEC-2, SIGLEC2, CD22 molecule External IDs OMIM: 107266 MGI: 88322 HomoloGene: 31052 GeneCards: CD22 | ||
Gene music using protein sequence of cd22 cd22 molecule
CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.
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CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice.
An immunotoxin, BL22, that targets this receptor is being tested at the NIH.