Species Human Entrez 3635 | Human Mouse Ensembl n/a | |
Aliases INPP5D, SHIP, SHIP-1, SHIP1, SIP-145, hp51CN, p150Ship, inositol polyphosphate-5-phosphatase D External IDs MGI: 107357 HomoloGene: 4046 GeneCards: INPP5D | ||
Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 is an enzyme that in humans is encoded by the INPP5D gene. INPP5D also called SHIP1 was also shown to be a negative regulator of BCR signalling in B cells.
Contents
Function
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Interactions
INPP5D has been shown to interact with DOK2, LYN, CD22, Grb2, CRKL, CD31, DOK1 and SHC1.
Medicines
Rosiptor (AQX-1125) is an INPP5D activator that is under development as an anti-inflammatory drug.