Entrez 10666 | Ensembl ENSG00000150637 | |
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Aliases CD226, DNAM-1, DNAM1, PTA1, TLiSA1, CD226 molecule External IDs MGI: 3039602 HomoloGene: 4787 GeneCards: CD226 | ||
CD226 (Cluster of Differentiation 226), PTA1 (outdated term, 'platelet and T cell activation antigen 1') or DNAM-1 (DNAX Accessory Molecule-1) is a protein that in humans is encoded by the CD226 gene which is located on chromosome 18q22.3.
Contents
Gene music using protein sequence of cd226 cd226 molecule
Structure and function
CD226 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. It is a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set.
CD226 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking CD226 with antibodies causes cellular activation.
References
CD226 Wikipedia(Text) CC BY-SA