The first round of the 2005–06 UEFA Cup began on 15 September 2005, which narrowed clubs down to 40 teams in preparation for the group stage.
Contents
First leg
All times CET
Second leg
All times CET
Hertha BSC won 4-1 on aggregate.
Auxerre 2-2 Levski Sofia on aggregate. Levski Sofia won on away goals.
Heerenveen won 5-2 on aggregate.
Basel won 6-0 on aggregate.
CSKA Sofia won 2-0 on aggregate.
Beşiktaş won 4-2 on aggregate.
Bolton Wanderers won 4-2 on aggregate.
Brøndby won 3-2 on aggregate.
Red Star Belgrade 1-1 Braga on aggregate. Red Star Belgrade won on away goals.
CSKA Moscow won 6-2 on aggregate.
Dinamo București won 5-2 on aggregate.
Rapid București won 2-1 on aggregate.
Espanyol won 3-1 on aggregate.
Germinal Beerschot 0-0 Marseille on aggregate. Marseille won 4-1 on penalties.
Grasshoppers won 4-1 on aggregate.
Strasbourg won 7-0 on aggregate.
Vitória de Guimarães won 4–0 on aggregate.
Halmstad 4-4 Sporting CP on aggregate. Halmstad won on away goals.
Hamburg won 2-1 on aggregate.
Dnipro won 5-1 on aggregate.
Krylya Sovetov Samara 6-6 AZ on aggregate. AZ won on away goals.
Lens won 5-3 on aggregate.
Litex Lovech won 3-2 on aggregate.
Maccabi Petah Tikva won 5-4 on aggregate.
Middlesbrough won 2-0 on aggregate.
Monaco won 5-1 on aggregate.
Palermo won 6-1 on aggregate.
PAOK 3-3 Metalurh Donetsk on aggregate. PAOK won on away goals.
Rennes won 3-1 on aggregate.
Roma won 5-1 on aggregate.
Sevilla won 2-0 on aggregate.
Shakhtar Donetsk won 6-1 on aggregate.
Lokomotiv Moscow won 5-3 on aggregate.
Slavia Prague won 4-1 on aggregate.
Tromsø won 2-1 on aggregate.
Steaua București won 6-1 on aggregate.
Stuttgart won 2–1 on aggregate.
Viking 2-2 Austria Wien on aggregate. Viking won on away goals.
Sampdoria won 2-1 on aggregate.
Zenit Saint Petersburg won 2-1 on aggregate.