|Covid-19|February 7 – John de la Pole, 2nd Duke of Suffolk, marries Lady Margaret Beaufort.
February 26 – Francesco Sforza enters Milan after a siege, becoming Duke of the city-state and founding a dynasty that would rule Milan for a century.
March – French troops under Guy de Richemont besiege the English commander in France, Edmund Beaufort, 1st Duke of Somerset, in Caen.
April 15 – Battle of Formigny: French troops under the Comte de Clermont defeat an English army under Sir Thomas Kyriel and Sir Matthew Gough which was attempting to relieve Caen.
May 8 – Jack Cade's Rebellion: Kentishmen revolt against King Henry VI of England.
May 9 – Abdal-Latif Mirza, a Timurid dynasty monarch, is assassinated.
May 13 – Charles VIII of Sweden, also serving as Carl I of Norway, is declared deposed from the latter throne in favor of Christian I of Denmark.
June 18 – Battle of Seven Oaks: Jack Cade's rebels are driven from London by loyal troops, bringing about the collapse of the rebellion.
July 6 – Caen surrenders to the French.
July 12 – Jack Cade is slain in a skirmish.
August 12 – Cherbourg, the last English territory in Normandy, surrenders to the French.
October 5 – Jews are expelled from Lower Bavaria by order of Duke Ludwig IX.
November 3 – The University of Barcelona is founded.
November 23 – First Siege of Krujë: Albanian victory; Ottoman army of approximately 100,000 men retreats from Albania.
Wolves enter Paris and kill 40 citizens.
Machu Picchu (Quechua: Machu Pikchu, "Old mountain") a pre-Columbian Inca site located 2,400 meters (7,875 ft) above sea level believed to be under construction.
Johannes Gutenberg has set up his movable type printing press as a commercial operation in Mainz by this date.
February 12 – Yejong of Joseon, Joseon King (d. 1469)
May 18 – Piero Soderini, Florentine statesman (d. 1513)
June 22 – Eleanor of Naples, Duchess of Ferrara (d. 1493)
July 25 – Jakob Wimpfeling, Renaissance humanist (d. 1528)
August 18 – Marko Marulić, Croatian poet (d. 1524)
September 25 – Ursula of Brandenburg, Duchess of Münsterberg-Oels and Countess of Glatz (d. 1508)
November 12 – Jacques of Savoy, Count of Romont, Prince of Savoy (d. 1486)
William Catesby, English politician (d. 1485)
Bartolomeo Montagna, Italian painter (d. 1523)
Heinrich Isaak, German-Dutch composer (d. 1517)
John Cabot, explorer (d. 1499)
Kamāl ud-Dīn Behzād, leader of the Herat school
Hieronymus Bosch, Dutch painter (d. 1516)
Gaspar Corte-Real, Portuguese explorer (d. 1501)
Juan de la Cosa, Spanish navigator and cartographer (d. 1510)
Josquin des Prez, Dutch composer (d. 1521)
Heinrich Isaac, Franco-Flemish composer (d. 1517)
Hugh Oldham, Bishop of Exeter (d. 1519)
Pietro Antonio Solari, Italian architect (d. 1493)
Petrus Thaborita, Dutch historian and monk (d. 1527)
January 9 – Adam Moleyns, Bishop of Chichester
February 9 – Agnès Sorel, mistress of Charles VII of France (b. 1421)
April 8 – Sejong the Great of Joseon, ruler of Korea (b. 1397)
May 2 – William de la Pole, 1st Duke of Suffolk, English military leader (born 1396)
May 9 – 'Abd al-Latif, ruler of Transoxonia
July 2 – Ranuccio Farnese il Vecchio, Italian condottiero (b. c.1390)
July 4 – James Fiennes, 1st Baron Saye and Sele
July 18 – Francis I, Duke of Brittany (b. 1414)
July 26 – Cecily Neville, Duchess of Warwick (b. 1424)
August 15 – Alberto da Sarteano, Italian Franciscan friar and papal legate (b. 1385)
August 27 – Reginald West, 6th Baron De La Warr, English politician (b. 1395)
August 31 – Isabella of Navarre, Countess of Armagnac (b. 1395)
September 16 – Louis Aleman, French cardinal
September 22 – William Tresham, English politician
November 3 – Paola Colonna, Lady of Piombino (born c.1378)
November 5 – John IV, Count of Armagnac (born 1396)
Year 1450 (MCDL) was a common year starting on Thursday (link will display the full calendar) of the Julian calendar.