Samiksha Jaiswal (Editor)

Type I cytokine receptor

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Type I cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands. These receptors are also known under the name hemopoietin receptors, and share a common amino acid motif (WSXWS) in the extracellular portion adjacent to the cell membrane. Members of the type I cytokine receptor family comprise different chains, some of which are involved in ligand/cytokine interaction and others that are involved in signal transduction.

Contents

Signal transduction chains

The signal transducing chains are often shared between different receptors within this receptor family.

  • The IL-2 receptor common gamma chain (also known as CD132) is shared between:
  • IL-2 receptor
  • IL-4 receptor
  • IL-7 receptor
  • IL-9 receptor
  • IL-13 receptor
  • IL-15 receptor
  • The common beta chain (CD131 or CDw131) is shared between the following type I cytokine receptors:
  • GM-CSF receptor
  • IL-3 receptor
  • IL-5 receptor.
  • The gp130 receptor ([Glycoprotein 130]) (also known as gp130, IL6ST, IL6-beta or CD130) is shared between:
  • IL-6 receptor
  • IL-11 receptor
  • IL-12 receptor
  • IL-27 receptor
  • Leukemia inhibitory factor receptor
  • Oncostatin M receptor
  • Examples

    Type I cytokine receptors include interleukin receptors, colony stimulating factor receptors and other cytokine receptors

    Interleukin receptors

  • Interleukin-2 receptor
  • Interleukin-3 receptor
  • Interleukin-4 receptor
  • Interleukin-5 receptor
  • Interleukin-6 receptor
  • Interleukin-7 receptor
  • Interleukin-9 receptor
  • Interleukin-11 receptor
  • Interleukin-12 receptor
  • Interleukin-13 receptor
  • Interleukin-15 receptor
  • Interleukin-21 receptor
  • Interleukin-23 receptor
  • Interleukin-27 receptor
  • Colony stimulating factor receptors

  • Erythropoietin receptor
  • GM-CSF receptor
  • G-CSF receptor
  • Hormone receptor/neuropeptide receptor

  • Growth hormone receptor
  • Prolactin receptor
  • Leptin receptor
  • Other

  • Oncostatin M receptor
  • Leukemia inhibitory factor receptor
  • References

    Type I cytokine receptor Wikipedia


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