Aliases IL23R Human Mouse Ensembl ENSG00000162594 | Species Human Entrez 149233 | |
External IDs MGI: 2181693 HomoloGene: 16930 GeneCards: IL23R | ||
Interleukin 23 receptor is a type I cytokine receptor. IL23R is its human gene.
Contents
Function
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.
Clinical significance
Three variants in the IL23R gene have been shown to protect against Crohn's disease and ulcerative colitis.
Model organisms
Model organisms have been used in the study of IL23R function. A conditional knockout mouse line called Il23rtm2a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping