Species Human Entrez 9180 | Human Mouse Ensembl ENSG00000145623 | |
Aliases OSMR, OSMRB, PLCA1, IL-31R-beta, IL-31RB, oncostatin M receptor External IDs OMIM: 601743 MGI: 1330819 HomoloGene: 2972 GeneCards: OSMR | ||
Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor, is one of the receptor proteins for oncostatin M, that in humans is encoded by the OSMR gene.
OSMR is a member of the type I cytokine receptor family. This protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events.
Clinical significance
The oncostatin M receptor is associated with primary cutaneous amyloidosis.
References
Oncostatin M receptor Wikipedia(Text) CC BY-SA