HUGO 6012 Locus Chr. X p22.3 | Alt. symbols CD123 OMIM 308385 | |
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Medical vocabulary what does interleukin 3 receptor alpha subunit mean
The interleukin-3 receptor (also known as CD123 antigen) is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune system.
Contents
- Medical vocabulary what does interleukin 3 receptor alpha subunit mean
- Cell types and function
- Possible drug target
- References
The gene coding for the receptor is located in the pseudoautosomal region of the X and Y chromosomes.
The receptor belongs to the type I cytokine receptor family and is a heterodimer with a unique alpha chain paired with the common beta (beta c or CD131) subunit.
The gene for the alpha subunit is 40 kilobases long and has 12 exons.
Cell types and function
The receptor, found on pluripotent progenitor cells, induces tyrosine phosphorylation within the cell and promotes proliferation and differentiation within the hematopoietic cell lines. It can found on Basophils and pDCs as well as some cDC among peripheral blood mononuclear cells
CD123 is expressed across acute myeloid leukemia (AML) subtypes, including leukemic stem cells.
Possible drug target
An experimental antibody-drug conjugate SGN-CD123A targets CD123 as a possible treatment for AML.