Entrez 23049 | Ensembl ENSG00000157106 | |
Aliases SMG1, 61E3.4, ATX, LIP, nonsense mediated mRNA decay associated PI3K related kinase External IDs MGI: 1919742 HomoloGene: 56697 GeneCards: SMG1 | ||
Serine/threonine-protein kinase SMG1 is an enzyme that in humans is encoded by the SMG1 gene. SMG1 belongs to the phosphatidylinositol 3-kinase-related kinase protein family.
Contents
Function
This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternative spliced transcript variants have been described, but their full-length natures have not been determined.
Interactions
References
SMG1 Wikipedia(Text) CC BY-SA