Entrez 5976 | Ensembl ENSG00000005007 | |
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Aliases UPF1, HNORF1, RENT1, pNORF1, smg-2, RNA helicase and ATPase External IDs MGI: 107995 HomoloGene: 2185 GeneCards: UPF1 | ||
Regulator of nonsense transcripts 1 is a protein that in humans is encoded by the UPF1 gene.
Contents
Function
This gene encodes a protein that is part of a post-splicing multiprotein complex, the exon junction complex, involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.
Interactions
UPF1 has been shown to interact with: