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Phosphatidylinositol 3 kinase related kinase

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Phosphatidylinositol 3-kinase-related kinases (PIKKs) are a family of Ser/Thr-protein kinases with sequence similarity to phosphatidylinositol-3 kinases (PI3Ks).

Contents

Members

The human PIKK family includes six members:

Structure

PIKKs proteins contain the following four domains:

  1. N-terminus FRAP-ATM- TRRAP (FAT) domain, Pfam PF02259
  2. kinase domain (KD; PI3_PI4_kinase),
  3. PIKK- regulatory domain (PRD), and
  4. C-terminus FAT-C-terminal (FATC) domain Pfam PF02260

References

Phosphatidylinositol 3-kinase-related kinase Wikipedia
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