Species Human Entrez 5584 | Human Mouse Ensembl ENSG00000163558 | |
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Aliases PRKCI, DXS1179E, PKCI, nPKC-iota, protein kinase C iota External IDs MGI: 99260 HomoloGene: 37667 GeneCards: PRKCI | ||
Protein kinase C iota type is an enzyme that in humans is encoded by the PRKCI gene.
Contents
Function
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.
Interactions
PRKCI has been shown to interact with: