Puneet Varma (Editor)

PRKCI

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
Species
  
Entrez
  
5584

Human
  
Ensembl
  
ENSG00000163558

PRKCI

Aliases
  
PRKCI, DXS1179E, PKCI, nPKC-iota, protein kinase C iota

External IDs
  
MGI: 99260 HomoloGene: 37667 GeneCards: PRKCI

Protein kinase C iota type is an enzyme that in humans is encoded by the PRKCI gene.

Contents

Function

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.

Interactions

PRKCI has been shown to interact with:

References

PRKCI Wikipedia


Similar Topics