Species Human Entrez 5883 | Human Mouse Ensembl ENSG00000172613 | |
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Aliases RAD9A, RAD9, RAD9 checkpoint clamp component A External IDs MGI: 1328356 HomoloGene: 32118 GeneCards: RAD9A | ||
Cell cycle checkpoint control protein RAD9A is a protein that in humans is encoded by the RAD9A gene.
Contents
Function
This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein is found to possess 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Use of alternative polyA sites has been noted for this gene.
Interactions
RAD9A has been shown to interact with:
References
RAD9A Wikipedia(Text) CC BY-SA