RAD1 homolog

Updated on Dec 11, 2024

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Species Human Entrez 5810		Human Mouse Ensembl ENSG00000113456

Aliases RAD1, HREC1, RAD1 homolog, RAD1 checkpoint DNA exonuclease External IDs MGI: 1316678 HomoloGene: 37695 GeneCards: RAD1

Cell cycle checkpoint protein RAD1 is a protein that in humans is encoded by the RAD1 gene.

Function
Interactions
References

Function

This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.

Interactions

RAD1 homolog has been shown to interact with:

HUS1,

RAD17, and

RAD9A,

References

RAD1 homolog Wikipedia

(Text) CC BY-SA

Contents

Function

Interactions

References