Species Human Entrez 5810 | Human Mouse Ensembl ENSG00000113456 | |
 | ||
Aliases RAD1, HREC1, RAD1 homolog, RAD1 checkpoint DNA exonuclease External IDs MGI: 1316678 HomoloGene: 37695 GeneCards: RAD1 | ||
Cell cycle checkpoint protein RAD1 is a protein that in humans is encoded by the RAD1 gene.
Contents
Function
This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
Interactions
RAD1 homolog has been shown to interact with:
References
RAD1 homolog Wikipedia(Text) CC BY-SA