Species Human Entrez 3364 | Human Mouse Ensembl ENSG00000136273 | |
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Aliases HUS1, hHUS1 checkpoint clamp component External IDs MGI: 1277962 HomoloGene: 37932 GeneCards: HUS1 | ||
Checkpoint protein HUS1 is a protein that in humans is encoded by the HUS1 gene.
Contents
Function
The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event.
Interactions
HUS1 has been shown to interact with: