Entrez 5884 | Ensembl n/a | |
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Aliases RAD17, CCYC, HR24L, RAD17SP, RAD24, RAD17 checkpoint clamp loader component External IDs MGI: 1333807 HomoloGene: 32117 GeneCards: RAD17 | ||
Cell cycle checkpoint protein RAD17 is a protein that in humans is encoded by the RAD17 gene.
Contents
Function
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported.
Interactions
RAD17 has been shown to interact with:
