Harman Patil (Editor)

Mequinol

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MedlinePlus
  
a682437

ATC code
  
D11AX06 (WHO)

Formula
  
C7H8O2

Routes ofadministration
  
Topical

Molar mass
  
124.1372 g/mol

Density
  
1.55 g/cm³

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AHFS/Drugs.com
  
International Drug Names

Legal status
  
CA: UnscheduledUS: ℞-only and UnscheduledIn general: unscheduled

Synonyms
  
4-Hydroxyanisole; para-Guaiacol

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Mequinol, MEHQ or 4-Methoxyphenol, is a phenol used in dermatology and organic chemistry.

Contents

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Dermatology

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Mequinol is a common active ingredient in topical drugs used for skin depigmentation. As a topical drug Mequinol is often mixed with tretinoin, a topical retinoid. A common formulation for this drug is an ethanolic solution of 2% Mequinol and 0.01% tretinoin by mass. Dermatologists commonly prescribe the drug to treat solar lentigines, liver spots, or age spots.

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Lower dosages of mequinol have been used in conjunction with a Q-switched laser to depigment skin in patients with disseminated idiopathic vitiligo.

Organic chemistry

In organic chemistry 4-methoxyphenol is used to inhibit the radical polymerization of monomers (e.g. acrylates or styrene monomers).

Preparation

4-Methoxyphenol is produced from p-benzoquinone and methanol via a free radical reaction.

Safety

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People can be exposed to 4-methoxyphenol in the workplace by breathing it in, skin absorption, swallowing it, skin contact, and eye contact. The National Institute for Occupational Safety and Health (NIOSH) has set a recommended exposure limit (REL) of 5 mg/m3 over an 8-hour workday.

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References

Mequinol Wikipedia