Girish Mahajan (Editor)

MCM3

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
Species
  
Entrez
  
4172

Human
  
Ensembl
  
ENSG00000112118

MCM3

Aliases
  
MCM3, HCC5, P1-P1.h, RLFB, minichromosome maintenance complex component 3

External IDs
  
MGI: 101845 HomoloGene: 1791 GeneCards: MCM3

DNA replication licensing factor MCM3 is a protein that in humans is encoded by the MCM3 gene.

Contents

Function

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.

Interactions

MCM3 has been shown to interact with:

  • CDC45-related protein,
  • CDC6,
  • DBF4,
  • MCM2
  • MCM3AP,
  • MCM5,
  • MCM7,
  • ORC4L, and
  • ORC5L.
  • References

    MCM3 Wikipedia


    Similar Topics