Species Human Entrez 4172 | Human Mouse Ensembl ENSG00000112118 | |
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Aliases MCM3, HCC5, P1-P1.h, RLFB, minichromosome maintenance complex component 3 External IDs MGI: 101845 HomoloGene: 1791 GeneCards: MCM3 | ||
DNA replication licensing factor MCM3 is a protein that in humans is encoded by the MCM3 gene.
Contents
Function
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.
Interactions
MCM3 has been shown to interact with: