Suvarna Garge (Editor)

CDC45 related protein

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
Species
  
Human

Entrez
  
8318

Human
  
Mouse

Ensembl
  
ENSG00000093009

CDC45-related protein

Aliases
  
CDC45, CDC45L, CDC45L2, PORC-PI-1, CDC45-related protein, cell division cycle 45

External IDs
  
MGI: 1338073 HomoloGene: 2616 GeneCards: CDC45

CDC45 is a protein that in humans is encoded by the CDC45L gene.

Contents

Function

The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenlyation sites of this gene are reported.

Interactions

CDC45-related protein has been shown to interact with:

  • MCM3,
  • MCM6,
  • MCM7,
  • ORC1L, and
  • ORC6L.

    • References

    CDC45-related protein Wikipedia
    (Text) CC BY-SA


    Similar Topics