Neha Patil (Editor)

MCM7

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Species
  
Entrez
  
4176

Human
  
Ensembl
  
ENSG00000166508


Aliases
  
MCM7, CDC47, MCM2, P1.1-MCM3, P1CDC47, P85MCM, PNAS146, PPP1R104, minichromosome maintenance complex component 7

External IDs
  
MGI: 1298398 HomoloGene: 4323 GeneCards: MCM7

DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene.

Contents

Function

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumor suppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Interactions

MCM7 has been shown to interact with:

References

MCM7 Wikipedia


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