Species Human Entrez 10014 | Human Mouse Ensembl ENSG00000108840 | |
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Aliases HDAC5, HD5, NY-CO-9, histone deacetylase 5 External IDs MGI: 1333784 HomoloGene: 3995 GeneCards: HDAC5 | ||
Histone deacetylase 5 is an enzyme that in humans is encoded by the HDAC5 gene.
Contents
Function
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
AMP-activated protein kinase regulation of the glucose transporter GLUT4 occurs by phosphorylation of HDAC5.
HDAC5 is involved in memory consolidation and suggests that development of more selective HDAC inhibitors for the treatment of Alzheimer's disease should avoid targeting HDAC5.
Interactions
Histone deacetylase 5 has been shown to interact with: