Species Human Entrez 139760 | Human Mouse Ensembl ENSG00000147262 | |
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Aliases GPR119, GPCR2, G protein-coupled receptor 119 External IDs MGI: 2668412 HomoloGene: 18670 GeneCards: GPR119 | ||
G protein-coupled receptor 119 also known as GPR119 is a G protein-coupled receptor that in humans is encoded by the GPR119 gene.
Contents
GPR119, along with GPR55 and GPR18, have been implicated as novel cannabinoid receptors.
Pharmacology
GPR119 is expressed predominantly in the pancreas and gastrointestinal tract in rodents and humans, as well as in the brain in rodents. Activation of the receptor has been shown to cause a reduction in food intake and body weight gain in rats. GPR119 has also been shown to regulate incretin and insulin hormone secretion. As a result, new drugs acting on the receptor have been suggested as novel treatments for obesity and diabetes.
Ligands
A number of endogenous and synthetic ligands for this receptor have been identified:
References
GPR119 Wikipedia(Text) CC BY-SA