Species Human Entrez 2267 | Human Mouse Ensembl ENSG00000104760 | |
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Aliases FGL1, HFREP1, HP-041, LFIRE-1, LFIRE1, fibrinogen like 1 External IDs MGI: 102795 HomoloGene: 37927 GeneCards: FGL1 | ||
Fibrinogen-like protein 1 (FGL-1) is a protein that is structurally related to fibrinogen. In humans, FLG-1 is encoded by the FGL1 gene. Four splice variants exist for this gene.
Contents
Function
Fibrinogen-like protein 1 is a member of the fibrinogen family of proteins, which also includes fibrinogen, fibrinogen-like protein 2, and clotting factors V, VIII, and XIII. FGL-1 is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of that are common to all members of the fibrinogen family. However, FGL-1 lacks the platelet-binding site, cross-linking region, and thrombin-sensitive site which allow the other members of the fibrinogen family to aid in fibrin clot formation.
Clinical significance
FGL-1 may play a role in the development of hepatocellular carcinomas.