Puneet Varma

Fibrinogen beta chain

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Species  Human
Entrez  2244
Human  Mouse
Ensembl  ENSG00000171564
Fibrinogen beta chain
Aliases  FGB, HEL-S-78p, fibrinogen beta chain
External IDs  MGI: 99501 HomoloGene: 3772 GeneCards: FGB

Fibrinogen beta chain, also known as FGB, is a gene found in humans and most other vertebrates with a similar system of blood coagulation.

The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.

Interactions

Fibrinogen beta chain has been shown to interact with Lipoprotein(a).

References

Fibrinogen beta chain Wikipedia


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