Puneet Varma


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Symbol  PENK
HUGO  8831
RefSeq  NM_006211
Entrez  5179
OMIM  131330
UniProt  P01210
Enkephalin httpsuploadwikimediaorgwikipediacommonsthu


An enkephalin (occasionally spelt encephalin) is a pentapeptide involved in regulating nociception in the body. The enkephalins are termed endogenous ligands, as they are internally derived and bind to the body's opioid receptors. Discovered in 1975, two forms of enkephalin were discovered, one containing leucine ("leu"), and the other containing methionine ("met"). Both are products of the proenkephalin gene.


  • Met-enkephalin is Tyr-Gly-Gly-Phe-Met.
  • Leu-enkephalin has Tyr-Gly-Gly-Phe-Leu.
  • What are endorphins and enkephalins

    Endogenous opioid peptides

    There are three well-characterized families of opioid peptides produced by the body: enkephalins, endorphins, and dynorphins. The met-enkephalin peptide sequence is coded for by the enkephalin gene; the leu-enkephalin peptide sequence is coded for by both the enkephalin gene and the dynorphin gene. The proopiomelanocortin gene (POMC) also contains the met-enkephalin sequence on the N-terminus of beta-endorphin, but the endorphin peptide is not processed into enkephalin.

    Enkephalin receptor

    The receptors for enkephalin are the delta opioid receptors and mu opioid receptors. Opioid receptors are a group of G-protein-coupled receptors, with other opioids as ligands as well. The other endogenous opioids are dynorphins (that bind to kappa receptors), endorphins (mu receptors), endomorphins, and nociceptin/orphanin FQ. The opioid receptors are ~40% identical to somatostatin receptors (SSTRs).


    Enkephalin Wikipedia

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