Entrez 2048 | Ensembl ENSG00000133216 | |
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Aliases EPHB2, Ephb2, Cek5, Drt, ETECK, Erk, Hek5, Nuk, Prkm5, Qek5, Sek3, Tyro5, CAPB, EK5, EPHT3, PCBC, EPH receptor B2, DRT, ERK External IDs MGI: 99611 HomoloGene: 37925 GeneCards: EPHB2 | ||
Function
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.
Animal studies
EphB2 is part of the NMDA signaling pathway and restoring expression rescues cognitive function in an animal model of Alzheimer's disease.
A recessive EphB2 gene is responsible for the crested-feather mutation in pigeons.
Interactions
EPH receptor B2 has been shown to interact with: