Species Human Entrez 5921 | Human Mouse Ensembl ENSG00000145715 | |
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Aliases RASA1, CM-AVM, CMAVM, GAP, PKWS, RASA, RASGAP, p120GAP, p120RASGAP, RAS p21 protein activator 1, p120 External IDs MGI: 97860 HomoloGene: 2168 GeneCards: RASA1 | ||
RAS p21 protein activator 1 or RasGAP (Ras GTPase activating protein), also known as RASA1, is a 120-kDa cytosolic human protein that provides two principal activities:
Contents
The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.
Domains
RasGAP contains one SH3 domain and two SH2 domains, a PH domain, and a GAP domain.
Interactions
RAS p21 protein activator 1 has been shown to interact with:
The mRNA can interact with Mir-132 microRNA; this process is linked to angiogenesis.
Disease Database
RASA1 gene variant database