Entrez 1828 | Ensembl ENSG00000134760 | |
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Aliases DSG1, CDHF4, DG1, DSG, EPKHE, EPKHIA, PPKS1, SPPK1, desmoglein 1 External IDs MGI: 94930 HomoloGene: 1463 GeneCards: DSG1 | ||
Function
Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein-1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus.
Interactions
Desmoglein-1 has been shown to interact with PKP3, PKP2, and PTPRT(PTPrho)
References
Desmoglein-1 Wikipedia(Text) CC BY-SA