Species Human Entrez 25920 | Human Mouse Ensembl ENSG00000188986 | |
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Aliases NELFB, COBRA1, NELF-B, Cofactor of BRCA1, negative elongation factor complex member B External IDs MGI: 1931035 HomoloGene: 121600 GeneCards: NELFB | ||
Cofactor of BRCA1, also known as COBRA1, is a human gene that encodes NELF-B.
Contents
Function
NELF-B is a subunit of negative elongation factor (NELF), which also includes NELF-A (WHSC2; MIM 606026), either NELF-C or NELF-D (TH1L; MIM 605297), and NELF-E (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660). COBRA1 was initially identified in a yeast two-hybrid screen using the BRCT1 domain of BRCA1 as bait.
Interactions
Cofactor of BRCA1 has been shown to interact with:
References
Cofactor of BRCA1 Wikipedia(Text) CC BY-SA