Species Human Entrez 7936 | Human Mouse Ensembl n/a | |
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Aliases NELFE, D6S45, NELF-E, RD, RDBP, RDP, negative elongation factor complex member E External IDs MGI: 102744 HomoloGene: 134736 GeneCards: NELFE | ||
Negative elongation factor E is a protein that in humans is encoded by the RDBP gene.
Contents
Function
The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.
Interactions
RDBP has been shown to interact with:
References
RDBP Wikipedia(Text) CC BY-SA