Neha Patil (Editor)

TH1L

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Species
  
Human

Entrez
  
51497

Human
  
Mouse

Ensembl
  
ENSG00000101158

TH1L

Aliases
  
NELFCD, NELF-C, NELF-D, TH1, TH1L, HSPC130, negative elongation factor complex member C/D

External IDs
  
MGI: 1926424 HomoloGene: 9496 GeneCards: NELFCD

Negative elongation factor C/D is a protein that in humans is encoded by the TH1L gene.

Contents

Function

The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini.

Interactions

TH1L has been shown to interact with:

  • ARAF,
  • Cofactor of BRCA1, and
  • RDBP.

    • References

    TH1L Wikipedia
    (Text) CC BY-SA


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