ATC code none PubChem CID 5315659 ChEMBL CHEMBL497318 Molar mass 316.48 g/mol | CAS Number 25654-31-3 ChemSpider 4474921 Formula C21H32O2 | |
 | ||
Cannabinoid profile cbg cannabigerol
Cannabigerol (CBG) is a cannabinoid found in the Cannabis genus of plants. Cannabigerol is found in higher concentrations in hemp rather than in varieties of Cannabis cultivated for high tetrahydrocannabinol (THC) content and their corresponding psychoactive properties. By the time most strains of cannabis are cultivated, they will have trace amounts of CBG, somewhere below 1%.
Contents
- Cannabinoid profile cbg cannabigerol
- Cbg cannabigerol international highlife
- Chemistry
- Uses
- Legal status
- United States
- Biosynthesis
- References
Cannabigerol has been found to act as a high affinity α2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist. It also binds to the CB2 receptor, but whether it acts as an agonist or antagonist at this site is not fully understood.
Cbg cannabigerol international highlife
Chemistry
It has two E/Z isomers.
Uses
Cannabigerol has been shown to relieve intraocular pressure, which may be of benefit in the treatment of glaucoma. It has been shown to improve a model of inflammatory bowel disease induced experimentally in mice. CBG can also inhibit the uptake of GABA in the brain, which can decrease anxiety and muscle tension.
Legal status
CBG is not scheduled by Convention on Psychotropic Substances.
United States
CBG is not scheduled at the federal level in the United States.
Biosynthesis
The biosynthesis of CBG begins loading a hexanoyl CoA onto a ketide synthetase assembly protein and subsequent condensation with three malonyl CoA molecules. This polyketide is cyclized to olivetolic acid via an olivetolic cyclase, and then prenylated with a 10 carbon isoprenoid using Geranyldiphosphate (GPP) and an aromatic prenyltransferase protein to biosynthesize a precursor to CBG, cannabichomenic acid (CBCA). CBCA is also a precursor to many cannabinoid compounds, including tetrahydrocannabinolic acid, or THCA. Finally, CBCA is cyclized into cannabigerolic acid (CBGA) using a cannabichromenic acid synthetase, and decarboxylation yields cannabigerol.