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Aaron Ciechanover

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Nationality
  
Israeli

Siblings
  
Joseph Ciechanover

Role
  
Biologist

Name
  
Aaron Ciechanover

Fields
  

Aaron Ciechanover Study by Israeli Nobel Prize winner Ciechanover found

Born
  
October 1, 1947 (age 76) Haifa, British Mandate of Palestine (now Israel) (
1947-10-01
)

Known for
  
Ubiquitin-mediated protein degradation

Notable awards
  
Spouse
  
Menucha Ciechanover (m. 1975)

Parents
  
Bluma Lubashevsky, Yitzhak Ciechanover

Awards
  
Nobel Prize in Chemistry, Albert Lasker Award for Basic Medical Research, EMET Prize in Life Sciences

Similar People
  
Avram Hershko, Irwin Rose, Alexander Varshavsky, Severo Ochoa

Jci s conversations with giants in medicine aaron ciechanover


Aaron Ciechanover ( , , ; אהרן צ'חנובר; born October 1, 1947) is an Israeli biologist, who won the Nobel prize in Chemistry for characterizing the method that cells use to degrade and recycle proteins using ubiquitin.

Contents

Winning the war on cancer interview aaron ciechanover technion nobel laureate


Biography

Aaron Ciechanover Prof Aaron Ciechanover Nobel Laureate in Chemistry

Ciechanover was born in Haifa, a year before the establishment of Israel. He is the son of Bluma (Lubashevsky), a teacher of English, and Yitzhak Ciechanover, an office worker. His family were Jewish immigrants from Poland before World War II.

Aaron Ciechanover Cell Death and Differentiation Early work on the

He earned a master's degree in science in 1971 and graduated from Hadassah Medical School in Jerusalem in 1974. On a visit to New York in 1977, Ciechanover spent two hours in a meeting with Rabbi Menachem M. Schneerson who discussed the nature of his research with him. He received his doctorate in biochemistry in 1981 from the Technion – Israel Institute of Technology in Haifa before conducting postdoctoral research in the laboratory of Harvey Lodish at the Whitehead Institute at MIT from 1981-1984. He is currently a Technion Distinguished Research Professor in the Ruth and Bruce Rappaport Faculty of Medicine and Research Institute at the Technion.

Ciechanover is a member of the Israel Academy of Sciences and Humanities, the Pontifical Academy of Sciences, and is a foreign associate of the United States National Academy of Sciences.

As one of Israel's first Nobel Laureates in Science, he is honored in playing a central role in the history of Israel and in the history of the Technion – Israel Institute of Technology.

Ciechanover is an atheist and does not believe in an afterlife, but strongly Jewish culturally.

Publications

  • Ciechanover, A., Hod, Y. and Hershko, A. (1978). A Heat-stable Polypeptide Component of an ATP-dependent Proteolytic System from Reticulocytes. Biochem. Biophys. Res. Commun. 81, 1100–1105.
  • Ciechanover, A., Heller, H., Elias, S., Haas, A.L. and Hershko, A. (1980). ATP-dependent Conjugation of Reticulocyte Proteins with the Polypeptide Required for Protein Degradation. Proc. Natl. Acad. Sci. USA 77, 1365–1368.
  • Hershko, A. and Ciechanover, A. (1982). Mechanisms of intracellular protein breakdown. Annu. Rev. Biochem. 51, 335–364.
  • Industry involvement

    Ciechanover has served on the Scientific Advisory Boards of the following companies: Rosetta Genomics (Chairman), BioLineRx, Ltd, StemRad, Ltd, Allosterix Ltd, Proteologics, Inc, MultiGene Vascular Systems, Ltd, Protalix BioTherapeutics and BioTheryX, Inc.

    Ciechanover is a member of the Advisory Board of Patient Innovation, a nonprofit, international, multilingual, free venue for patients and caregivers of any disease to share their innovations.

    Awards

  • In 2000, Ciechanover received the Albert Lasker Award for Basic Medical Research.
  • In 2003, he was awarded the Israel Prize, for biology.
  • In 2004, he was awarded Nobel Prize in Chemistry for his discovery with Avram Hershko and Irwin Rose, of ubiquitin-mediated protein degradation. The ubiquitin-proteasome pathway has a critical role in maintaining the homeostasis of cells and is believed to be involved in the development and progression of diseases such as: cancer, muscular and neurological diseases, immune and inflammatory responses.
  • In 2006, he was awarded the Sir Hans Krebs Medal
  • References

    Aaron Ciechanover Wikipedia


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