Avram Hershko

Updated on Dec 31, 2023

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Nationality Israel Spouse Judy Leibowitz (m. 1963) Children 3 Fields Chemistry		Name Avram Hershko Role Biochemist

Born Hersko Ferenc 31 December 1937 (age 86) Karcag, Hungary ( 1937-12-31 ) Known for ubiquitin-mediated protein degradation Education Hebrew University of Jerusalem (1969), Hebrew University of Jerusalem (1965) Awards Nobel Prize in Chemistry Similar People Aaron Ciechanover, Irwin Rose, Alexander Varshavsky, Severo Ochoa
Notable awards Nobel Prize in Chemistry

Prof avram hershko science as an adventure

Avram Hershko (Hebrew: אברהם הרשקו‎‎; born 31 December 1937) is a Hungarian-born Israeli biochemist and Nobel laureate in Chemistry.

Avram Hershko Prof Avram Hershko Nobel Laureate in Chemistry 2004 CFHU

Avram hershko technion lessons from my life in science

Biography

Avram Hershko Avram Hershko to give the Hans Neurath Lecture on May 8

Hershko was born Herskó Ferenc in Karcag, Hungary, the son of Shoshana Margit and Moshe Hershko, both teachers. Hershko emigrated to Israel in 1950. He received his M.D. in 1965 and his Ph.D in 1969 from the Hebrew University-Hadassah Medical School, Jerusalem, Israel. He is currently a Distinguished Professor at the Rappaport Faculty of Medicine at the Technion in Haifa.

Avram Hershko Radio Prague Hungarianborn Avram Hershko wins Nobel

Along with Aaron Ciechanover and Irwin Rose, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation. The ubiquitin-proteasome pathway has a critical role in maintaining the homeostasis of cells and is believed to be involved in the development and progression of diseases such as cancer, muscular and neurological diseases, and immune and inflammatory responses.

Avram Hershko Cell Death and Differentiation Early work on the

His contributions to science directly helped cure one of his long-time friends of cancer.

Honours and awards

Avram Hershko The Body39s Protein Cleaning Machine The New York Times

1987 – Weizmann Prize for Sciences (Israel)

1994 – Israel Prize in biochemistry

1999 – Gairdner Foundation International Award Canada (with A. Varshavsky)

2000 – Albert Lasker Award for Basic Medical Research (with A. Ciechanover and A. Varshavsky).

2000 – Alfred P. Sloan, Jr. Prize (with A. Varshavsky)

2001 – Louisa Gross Horwitz Prize from Columbia University

2001 – Massry Prize from the Keck School of Medicine, University of Southern California

2001 – Wolf Prize in Medicine (Israel), jointly with Alexander Varshavsky, for 'the discovery of the ubiquitin system of intracellular protein degradation and the crucial functions of this system in cellular regulation."

2002 – The EMET Prize for Art, Science and Culture

2002 – E.B. Wilson Medal

2003 – Foreign Associate, National Academy of Sciences, USA

2004 – Nobel Prize in Chemistry for his discovery with Aaron Ciechanover and Irwin Rose, of ubiquitin-mediated protein degradation.

Publications

Hershko, A., Ciechanover, A., Heller, H., Haas, A.L., and Rose I.A. (1980) "Proposed role of ATP in protein breakdown: Conjugation of proteins with multiple chains of the polypeptide of ATP-dependent proteolysis". Proc. Natl. Acad. Sci. USA 77, 1783–1786.

Hershko, A., Heller, H., Elias, S. and Ciechanover, A. (1983) Components of ubiquitin-protein ligase system: resolution, affinity purification and role in protein breakdown. J. Biol. Chem. 258, 8206–8214.

Hershko, A., Leshinsky, E., Ganoth, D. and Heller, H. (1984) ATP-dependent degradation of ubiquitin-protein conjugates. Proc. Natl. Acad. Sci. USA 81, 1619–1623.

Hershko, A., Heller, H., Eytan, E. and Reiss, Y. (1986) The protein substrate binding site of the ubiquitin-protein ligase system. J. Biol. Chem. 261, 11992-11999.

Ganoth, D., Leshinsky, E., Eytan, E., and Hershko, A. (1988) A multicomponent system that degrades proteins conjugated to ubiquitin. Resolution of components and evidence for ATP-dependent complex formation. J. Biol. Chem. 263, 12412-1241.

Sudakin, V., Ganoth, D., Dahan, A., Heller, H., Hershko, J., Luca, F.C., Ruderman, J.V. and Hershko, A. (1995). The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol. Biol. Cell 6, 185–198.

Involvement with biotechnology

Professor Hershko serves on the Scientific Advisory Board of Oramed Pharmaceuticals.

References

Avram Hershko Wikipedia

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