Puneet Varma


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Aliases  ARF1
Human  Mouse
Ensembl  ENSG00000143761
Species  Human
Entrez  375
External IDs  MGI: 99431 HomoloGene: 133930 GeneCards: ARF1

ADP-ribosylation factor 1 is a protein that in humans is encoded by the ARF1 gene.



ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

The major mechanism of action of Brefeldin A is through inhibition of ARF1.


ARF1 has been shown to interact with:

  • CHRM3,
  • COPB1,
  • GGA3, and
  • PLD2.
  • References

    ARF1 Wikipedia

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