Samiksha Jaiswal (Editor)

PLD2

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Aliases
  
PLD2

Human
  
Mouse

Ensembl
  
ENSG00000129219

Species
  
Human

Entrez
  
5338

PLD2

External IDs
  
MGI: 892877 HomoloGene: 55672 GeneCards: PLD2

Phospholipase D2 is an enzyme that in humans is encoded by the PLD2 gene.

Contents

Function

Phosphatidylcholine (PC)-specific phospholipases D (PLDs) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. Activation of PC-specific PLDs occurs as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. PC-specific PLDs have been proposed to function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control.[supplied by OMIM]

Interactions

PLD2 has been shown to interact with:

Inhibitors

  • N-(2-(1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide: 75-fold selective versus PLD1, IC50 = 20 nM.

    • References

    PLD2 Wikipedia
    (Text) CC BY-SA