|Covid-19|January 1 – Minimum date value for a datetime field in SQL Server (up to SQL Server 2005) due to it being the first full year after Britain adopted the Gregorian calendar. You may also see this value in Oracle database's date fields as a starting value (instead of null) if the application supports either database installations (Oracle or SQL Server).
January 29 – After a month's absence, Elizabeth Canning returns to her mother's home in London and claims that she was abducted. The following criminal trial causes uproar.
March 1 – Sweden adopts the Gregorian calendar by skipping the 11 days difference between it and the Julian calendar and letting February 17 be followed directly by March 1.
March 17 – First official Saint Patrick's Day.
May 1 – Species Plantarum is published by Linnaeus (adopted by the International Code of Botanical Nomenclature as the formal start date of the scientific classification of plants).
June 7 – The British Museum is established in London by Act of Parliament.
July – The Parliament of Great Britain passes Lord Hardwicke's Marriage Act "for the Better Preventing of Clandestine Marriage" in England and Wales; it comes into effect in 1754.
July 7 – The Parliament of Great Britain's Jewish Naturalization Act receives royal assent, allowing naturalization to Jews; it is repealed in 1754.
October 31 – Virginia Lieut. Gov. Robert Dinwiddie commissions 21-year-old militia Maj. George Washington to dissuade the French from occupying the Ohio Country.
James Lind writes A Treatise of the Scurvy.
Robert Wood publishes The ruins of Palmyra; otherwise Tedmor in the desart in English and French, making the ancient Syrian city of Palmyra known to the West.
The Cramer family starts a brewing operation at Warstein in North-Rhine Westphalia, origin of the Warsteiner brand.
Coining of the term "anthropomorphism"
February 12 – François-Paul Brueys d'Aigalliers, French admiral (d. 1798)
February 20 – Louis-Alexandre Berthier, French marshal (d. 1815)
March 8 – William Roscoe, English writer (d. 1831)
March 9 – Jean-Baptiste Kléber, French general (d. 1800)
March 13 – Louise Marie Adélaïde de Bourbon-Penthièvre, Duchess of Orléans, heiress, wife of Philippe Égalité (d. 1821)
March 26 – Benjamin Thompson, American physicist and inventor (d. 1814)
April 3 – Simon Willard, American horologist (d. 1848)
May 13 – Lazare Carnot, French general, politician and mathematician (d. 1823)
June 5 – Johann Friedrich August Göttling, German chemist (d. 1809)
July 9 – William Waldegrave, 1st Baron Radstock, British admiral, Governor of Newfoundland (d. 1825)
August 10 – Edmund Randolph, American politician (d. 1813)
August 12 – Thomas Bewick, English wood engraver (d. 1828)
September 10 – John Soane, English architect (d. 1837)
October 27 – Jean-Baptiste de Lavalette, French general (d. 1794)
November 6 – Jean-Baptiste Breval, French composer (d. 1823)
December 3 – Samuel Crompton, English inventor (d. 1827)
Francesc Antoni de la Dueña y Cisneros, Spanish bishop (d. 1821)
John Haggin, "Indian fighter" and one of the earliest settlers of Kentucky (d. 1825)
Phillis Wheatley, African-born poet (d. 1784)
January 11 – Sir Hans Sloane, Irish physician (b. 1660)
January 14 – George Berkeley, Irish philosopher (b. 1685)
January 23 – Louise Bénédicte de Bourbon, French royal princess and saloniste (b. 1676)
February 16 – Giacomo Facco, Italian composer (b. 1676)
May 23 – Franciszka Urszula Radziwiłłowa, Polish dramatist (b. 1705)
June 7 – Archibald Cameron of Locheil, last Scottish Jacobite to be executed for treason (b. 1707)
June 10 – Joachim Ludwig Schultheiss von Unfriedt, German architect (b. 1678)
August 6 – Georg Wilhelm Richmann, Russian physicist (struck by lightning) (b. 1711)
August 19 – Balthasar Neumann, German architect and military engineer (b. 1687)
December 15 – Richard Boyle, 3rd Earl of Burlington, English architect (b. 1694)
December 25 – Godolphin Arabian, thoroughbred stallion (b. c.1724)
1753 (MDCCLIII) was a common year starting on Monday (dominical letter G) of the Gregorian calendar and a common year starting on Friday (dominical letter C) of the Julian calendar, the 1753rd year of the Common Era (CE) and Anno Domini (AD) designations, the 753rd year of the 2nd millennium, the 53rd year of the 18th century, and the 4th year of the 1750s decade. As of the start of 1753, the Gregorian calendar was 11 days ahead of the Julian calendar, which remained in localized use until 1923.