Entrez 23534 | Ensembl ENSG00000064419 | |
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Aliases TNPO3, IPO12, LGMD1F, MTR10A, TRN-SR, TRN-SR2, TRNSR, transportin 3 External IDs MGI: 1196412 HomoloGene: 40848 GeneCards: TNPO3 | ||
Function
TNPO3 is a nuclear import receptor for serine/arginine-rich (SR) proteins, including Serine/arginine-rich splicing factor 1, which are essential precursor-mRNA splicing factors.
Clinical significance
The TNPO3-IRF5 locus is implicated in primary biliary cirrhosis and systemic sclerosis.
References
Transportin-3 Wikipedia(Text) CC BY-SA