Species Human Entrez 7037 | Human Mouse Ensembl ENSG00000072274 | |
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Aliases TFRC, CD71, T9, TFR, TFR1, TR, TRFR, p90, IMD46, transferrin receptor External IDs MGI: 98822 HomoloGene: 2429 GeneCards: TFRC | ||
Transferrin receptor protein 1 (TfR1), also known as Cluster of Differentiation 71 (CD71), is a protein that in humans is encoded by the TFRC gene. TfR1 is required for iron import from transferrin into cells by endocytosis.
Contents
Structure and function
TfR1 is a transmembrane glycoprotein composed of two disulfide-linked monomers joined by two disulfide bonds. Each monomer binds one holo-transferrin molecule creating an iron-Tf-TfR complex which enters the cell by endocytosis.
Clinical significance
TfR1 as a potential new target in cases of human leukemia & lymphoma. InatherYs, in Évry, France, developed a candidate drug, INA01 antibody (anti-CD71) that showed efficacy in pre-clinical studies in the therapy of two incurable orphan oncohematological diseases: the adult T cell leukemia (ATLL) caused by HTLV-1 and the Mantle cell lymphoma (MCL).
Interactions
TfR1 has been shown to interact with GABARAP and HFE.