Entrez 11337 | Ensembl ENSG00000170296 | |
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External IDs MGI: 1861742 HomoloGene: 134119 GeneCards: GABARAP | ||
Gamma-aminobutyric acid receptor-associated protein is a protein that in humans is encoded by the GABARAP gene.
Contents
Function
Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton.
Moreover, GABARAP has an important function in autophagosome mediated autophagy, since it is crucial for autophagosome formation and sequestration of cytosolic cargo into double-membrane vesicles, leading to subsequent degradation after fusion with lysosomes. In addition, GABARAP can mediated selective autophagy because it binds to so-called autophagic receptors (e.g. p62, NBr1), which bind and recruit specific cargo.
Interactions
GABARAP has been shown to interact with TFRC, ULK1 and GABRG2.